Role of gut–kidney axis in renal diseases and IgA nephropathy

Rôle de l'axe intestin/rein dans les maladies rénales et la néphropathie à IgA

Renato C Monteiro , Laureline Berthelot (1)

1 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

Purpose of review Growing evidence show the importance of gut/kidney axis in renal diseases. Advances in gut microbiome sequencing, associated metabolites, detection of gut permeability and inflammation provide new therapeutic strategies targeting gut for kidney diseases and particularly for Immunoglobulin A (IgA) nephropathy (IgAN). Recent findings The diversity and composition of gut flora have been recently deeply explored in kidney diseases. Modulation and depletion of microbiota in animal models allowed the understanding of molecular mechanisms involved in the crosstalk between gut, immune system and kidney. New clinical trials in order to positively modulate microbiota result in improvement of gastrointestinal disorders and inflammation in patients suffering with kidney diseases. Summary The investigation of gut alterations in kidney diseases open new therapeutic strategies. In IgAN, targeted treatments for intestinal inflammation and modifications of gut microbiota seem promising.

Mots clés: IgA nephropathy; intestinal inflammation; kidney diseases; microbiota

Domaines: Sciences du Vivant [q-bio]

Renato C Monteiro, Laureline Berthelot. Role of gut–kidney axis in renal diseases and IgA nephropathy. Current Opinion in Gastroenterology, 2021, 37 (6), pp.565-571. ⟨10.1097/MOG.0000000000000789⟩. ⟨hal-04536993⟩